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* Correspondence: Prakash Shankaran, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Despite that, patients carrying this protective variant showed lower insulin autoimmunity, residual cell function, higher C-peptide levels, better glycemic control, and a lower risk for diabetes complications (65, 66)

The CYP3A4 induction and inhibition assays also highlight the potential of iHLOs for dynamic pharmacological testing, a key aspect of drug safety evaluations 35

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